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Betamethasone valerate

Name: Betamethasone valerate
Brand: TargetMol
SKU: T1163
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1163Cas No. 2152-44-5

Alias Luxiq, Betnovate, Betamethasone 17-valerate, Betaderm

Betamethasone valerate (Luxiq) is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.

Betamethasone valerate

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Purity: 99.32%

Catalog No. T1163Alias Luxiq, Betnovate, Betamethasone 17-valerate, BetadermCas No. 2152-44-5

Betamethasone valerate (Luxiq) is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$41	In Stock	In Stock
100 mg	$61	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.32%

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Betamethasone valerate AI Summary

Betamethasone valerate exhibits a broad spectrum of bioactivities, prominently including anti-inflammatory and antiviral properties. In a murine chronic irritative contact dermatitis model, it significantly inhibited ear swelling (41.0%) and ear weight (38.0%) induced by TPA, and MPO activity (67.0%). It also demonstrated anti-inflammatory effects in a murine topical allergic contact dermatitis model, inhibiting TNFalpha by 75.0% at a dose of 0.003 mg. Its activity was comparable to betamethasone 17-valerate in the Tonelli croton oil ear tests with a topical potency of 1.0. Additionally, Betamethasone valerate showed a permeability coefficient in human skin of log Kp = -6.12, indicating low skin permeability. In antiviral studies, it inhibited SARS-CoV-2 induced cytotoxicity in Caco-2 cells (15.28% at 10 μM) and VERO-6 cells (0.09% at 10 μM) after 48 hours. It also showed a 2.908% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 μM. Moreover, it demonstrated potential efficacy against the SARS-CoV-2 (USA-WA1/2020 strain) with a hit score of -0.1439. Betamethasone valerate showed relative bioactivity in various assays, including inhibition of Plasmodium falciparum proliferation, liver enzyme composite activity, and sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells. It also exhibited in vivo inverse agonist activity at RORgamma in a mouse model of imiquimod-induced skin inflammation with 72.0% attenuation of epidermal hyperplasia at a concentration of 0.01%. In human receptor binding assays, it showed a stronger inhibitory potential against human NR3C1 with an AC50 of 4.0 nM, despite generally having AC50 values greater than 10,000 nM for most other targets. Betamethasone valerate has a potency of 360.0 relative to fluocinolone 16,17-acetonide in the human vasoconstrictor test..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Betamethasone valerate (Luxiq) is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.
Synonyms	Luxiq, Betnovate, Betamethasone 17-valerate, Betaderm

Chemical Properties

Molecular Weight	476.58
Formula	C₂₇H₃₇FO₆
Cas No.	2152-44-5
Smiles	C[C@@]12[C@@](OC(CCCC)=O)(C(CO)=O)[C@@H](C)C[C@]1([C@]3([C@](F)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]
Relative Density.	1.24g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 58 mg/mL (121.7 mM), Sonication is recommended.

DMSO: 95 mg/mL (199.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0983 mL	10.4914 mL	20.9828 mL	104.9142 mL
5 mM	0.4197 mL	2.0983 mL	4.1966 mL	20.9828 mL
10 mM	0.2098 mL	1.0491 mL	2.0983 mL	10.4914 mL
20 mM	0.1049 mL	0.5246 mL	1.0491 mL	5.2457 mL
50 mM	0.0420 mL	0.2098 mL	0.4197 mL	2.0983 mL
100 mM	0.0210 mL	0.1049 mL	0.2098 mL	1.0491 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc